RiSE - Roche internship for Scientific Exchange - Epigenetic reprogramming and transcriptional regulation in response to pharmacological activation (9 months)
At Roche, we believe it’s urgent to deliver medical solutions right now - even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are brave in both decision and action, we believe that good business means a better world.
The Rare Disease group is focused on discovery and development of novel therapeutics for genetically defined diseases with high unmet medical need. The group lies within the Neuroscience, Ophthalmology and Rare Disease (NORD) Disease Translation Area (DTA), part of the Pharma Research and Early Development (pRED) organization.
The RiSE program (Roche Internships for Scientific Exchange) offers the most talented postgraduate students the opportunity to improve their competencies and to gain valuable work experience within our diverse environment. The position will be based in Basel, Switzerland.
In this position you will use patient derived stem cell lines to explore allele specific regulation of gene transcription by epigenetic factors. In particular, the goal of this task will be to establish changes in chromatin organization with pharmacological treatment aimed at enhancing gene expression. Using the results of this work, if time permits, you will investigate the translatability in samples collected from in vivo experiments.
During the internship your tasks will include:
- Culturing patient derived neuronal stem cell lines, and maintaining cultures with longer duration differentiation protocols
- Designing and conducting experiments to study pharmacological treatment effects in disease cell lines (i.e. establishing a treatment and sample collection schedule to assess changes over time)
- Establishing assays to probe epigenetic reprogramming at specific loci (e.g. bisulfite sequencing, ICC) in response to treatment induced transcriptional activation.
- Performing data analysis with functional support
- Participate in group discussions and share lab workspace with a small team composed of 2 research associates
- Reporting progress to a discovery project leader scientist who will also be your mentor and supervisor
- Active problem solving and contribution to team discussion
Who you are:
You’re someone who wants to influence your own development. You are looking for a company where you receive a chance to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you. As go-getter you actively drive the quality of the requirements.
You are a self-starter and someone who is looking to get out of your comfort zone and to learn new things that will encourage you and advance your career. While being part of a strong mentoring team of neuroscientists, biologists, and highly experienced associates, you will be expected to independently guide key aspects of the project, and expand the analysis as you see necessary. Furthermore, for a short project like this one, you have a very specific skill set and self-reliance.
Moreover, you are/have:
- Enrolled in PhD or medical degree program at a university
- A strong background in molecular cell biology with prior research experience in chromatin biology
- Some experience in working with different cell culture systems, preferably according to BSL2 requirements
- Excellent communication skills and good team spirit with the ability to tackle problems independently
- High level of English speaking and writing skills
Information about application documents and start date:
The preferred start date of this internship is February 2019. Along with your CV, please include a cover letter outlining how your research interests align with this job posting, career plans, and expectations for this internship. Applications also need to include a letter from your academic supervisor supporting your RiSE application and 2-3 letters of recommendation from science/medical professionals. Finally, please note that non-EU/EFTA nationals have to successfully apply for a Swiss work permit.
Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
If you still have questions then please check our FAQs and videos on careers.roche.ch/faq.
Wer wir sind
At Roche, 94,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Roche is an equal opportunity employer.
- Standort Switzerland, Aargau, Basel Headquarter
- Funktion Vocational & Development Programs
- Subfunktion Internship
- Arbeitszeit Full time
- Funktionsebene Entry Level
- Art der Anstellung Temporary (Fixed Term)
- Firma/ Division Roche Pharmaceuticals
- Posted since 2018/11/16
- Job-ID 201811-126133
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