RiSE - Roche internship for Scientific Exchange - Incorporate human iPSC-derived microglia to establish a novel in vitro model of the blood-brain barrier (from October 2020, 9 months)

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RiSE - Roche internship for Scientific Exchange - Incorporate human iPSC-derived microglia to establish a novel in vitro model of the blood-brain barrier (from October 2020, 9 months)

At Roche, we believe it’s urgent to deliver medical solutions right now - even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

The Position
The RiSE program (Roche Internships for Scientific Exchange) is a highly competitive student research program at Roche. It offers the most talented postgraduate PhD and medical degree students the opportunity to be fully integrated into our interdisciplinary and international industry R&D environment. As a RiSE student you will enhance your competencies, gain valuable work experience with us, and eventually become part of a world-wide network of RiSE Alumni.

The Neuroscience and Rare Diseases Discovery and Translational Area (NRD DTA) is developing medicines for a range of serious neurological diseases, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, autism, spinal muscular atrophy, and Huntington’s disease.

As RiSE student in the NRD DTA you will join our group in the NRD Research department. Embedded in a cross-functional team at the Roche Innovation Center Basel, Switzerland, you will build and characterize a novel human induced pluripotent stem cell (hiPSC)-derived co-culture system between microglia and an existing cellular model of the human blood-brain barrier (BBB). We are seeking a highly motivated postgraduate researcher to join us in this task. You will be hosted and mentored by Roche scientists in NRD DTA and Therapeutic Modalities who will guide you through your research and provide you with the needed work infrastructure and collaborative network.

During the internship your tasks will include

  • Incorporate hiPSC-derived microglia in a hiPSC-derived model of the BBB
  • Characterize the effects of microglia incorporation in the BBB model
  • Perform functional assays to modulate the activity of the microglia
  • Perform transport, phenotypic and other assays to assess the effects of microglia activation
  • Design and execute validation experiments
  • Formulate hypotheses based on the literature and the results obtained during the project and shape the project accordingly
  • Present your progress in internal meetings and draft a publication of the data

Who you are
You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

Moreover you are/have

  • Enrolled in a PhD or medical degree program at a university and are looking to expand your experience with an industry internship (must still be enrolled at university for 50% of the duration of the stay at Roche)
  • Ideally are at the final stage of doctoral studies in neuroscience, vascular biology, or stem cell biology; having a background in glia, neuroimmunology or the BBB is a plus
  • Experience in stem cell differentiation, ideally into cells of the central nervous system
  • Experience in cellular assays
  • Experience in flow cytometry and advanced light microscopy (fluorescent, confocal; experience in live-cell imaging and light sheet is a plus)
  • Highly collaborative mind-set; comfortable working in a team setting and in a multifunctional and multicultural environment.
  • Employing your scientific curiosity with rigor
  • Excellent presentation, writing and communication skills
  • Fluency in English

The position can start in October 2020 and is set for nine months.

Applications need to include a CV and a cover letter, as well as a letter from your academic supervisor supporting your application to the RiSE Program.

Please note that due to regulations non-EU/EFTA citizens have to provide a certificate from the university stating that an industry internship is mandatory as part of the university training.

Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

If you still have questions, then please check our FAQs and videos on careers.roche.ch/faq.

More information about career start at Roche you can find here.

Tags: ROiQQ ROiLS ROiEE ROiTEC ROiCS RiSE

Roche is an equal opportunity employer.

Vocational & Development Programs, Vocational & Development Programs > Internship

Wer wir sind

At Roche, 98,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer.

Job-Fakten

  • StandortSwitzerland,Basel-City,Basel
  • Funktion Vocational & Development Programs
  • Subfunktion Internship
  • Arbeitszeit Full time
  • Funktionsebene Entry Level
  • Art der Anstellung Temporary (Fixed Term)
  • Firma/ Division Roche Pharmaceuticals
  • Posted since 2020/08/07
  • Job-ID 202008-120862

Kontaktieren Sie uns

Dr. Volker Herdtweck-Nietzel

Online bewerben!

Am 28.08.2020 veröffentlicht. Originalanzeige