Research Associate in Neuroimmunology (M/F/D)

Responsibilities:

• Investigate, develop and implement new biochemical assays from cells, preclinical models, and human tissue to advance priority pipeline programs
• Develop functional assays in iPSC-derived/primary microglial, neuronal and astrocyte systems to study neuron-glia cell interactions.
• Design, execute, analyze and interpret complex in-vitro and in vivo studies in the area of neuroimmunology.
• Leverage a combination of biochemical approaches, combined with high-content/resolution microscopy to characterize cellular models of astrocyte and microglia biology.
• Working effectively with internal and external collaborators to advance ongoing exploratory and portfolio projects.
• Establish SOPs, adapt new protocols from literature and maintain electronic laboratory notebooks.
• Present data to the team.

Qualifications:

• Master’s degree in neuro-immunology, cell/molecular biology or biochemistry.
• Prior experience in neuroscience drug discovery R&D is an advantage.
• Certification for performing in vivo animal experiments required. Expertise in in vivo animal dosing (i.p., i.v., p.o.), perfusion, tissue collection and preparation for biochemical and immunoassays is an advantage.
• Expertise working with primary rodent glial and neuron cultures, as well as iPSC derived model systems, as applied to target discovery, validation, and cellular proof-of-action studies.
• Broad hands-on experience with various gene expression, immunoassay, and molecular profiling approaches applied to cells and brain tissues (human and rodents)
• Knowledge of various genetic delivery (plasmid and viral) and disruption (Crispr and RNAi) techniques is an advantage
• Skillset in developing robust and reproducible imaging-based cell functional assays
• Ability to independently design, execute, and analyze experiments
• Strong critical thinking, communication, organization, and presentation skills

General:

• Excellent computer-based data management and record-keeping skills; a background in basic biostatistical data analysis is a plus
• Excellent communication skills to report your results to the team; good command of the English language is a must (speaking and writing)
• You must like an independent working style and troubleshooting in a multi-departmental and international pharma research environment with the motivation to build your Matrix-leadership skills

Wer wir sind

At Roche, 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche is an equal opportunity employer.

Job-Fakten

• StandortSwitzerland,Basel-City,Basel
• Funktion Research & Development
• Subfunktion Research
• Arbeitszeit Full time
• Funktionsebene Entry Level
• Art der Anstellung Regular
• Firma/ Division Roche Pharmaceuticals
• Posted since 2021/10/25
• Job-ID 202110-130006

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